Category
Disease Models
Animal Models and Apparatus of Sleep Disorders
June 16, 2023
Sleep problems affect a significant portion of the population, with over half of people in the United States reporting difficulties with sleep or excessive…
Maximum Volume of Oxygen (VO2) Testing in Rodents
February 8, 2023
Maximum volume of oxygen (VO2max) is a measure of the maximum amount of oxygen that an individual can consume during exercise. VO2max is expressed in…
Rodent Models of Social Anxiety Disorders
November 19, 2021
Fear is something we try to do without in life – which is also the very reason they exist, to provide salient physical and psychological cues and help us…
Animal Models of Migraine Headaches
August 16, 2021
Migraines are best known for their severe, pulsating headaches, along with more variable associated symptoms such as hypersensitivity to lights and sounds,…
Mouse Models of Glioblastoma
June 28, 2021
Glioblastoma, also known as glioblastoma multiforme (GBM), is a high-grade (grade 4) glioma brain tumor. It’s considered an aggressive tumor, as it’s related…
Relevance of Animal Models of Eating Disorders
June 25, 2021
We are what we eat. In the modern world, there is much pressure to eat well and keep fit. The simple task of eating and surviving is made so much harder with…
Animal Models of Korsakoff Syndrome
June 21, 2021
Alcohol, a cultural component in most of the western world, is a trillion dollars contributor to the global economy as well as a billion dollars of medical…
Rodent Models for Alzheimer’s Disease in Drug Testing
June 18, 2021
The number of people living with Alzheimer’s Disease is rapidly increasing with estimates that more than 12.7 million people over the age of 65 will be…
Mouse Models of Restricted Repetitive Behavior in Autism
June 7, 2021
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder for behavioral deficits. For more information on autism, check out this article.…
Modeling Genetic Diversity in Alzheimer's Disease
June 4, 2021
With the increase in life expectancy, there’s been a growing concern about the prevalence and incidence of Alzheimer’s disease (AD), which is the major cause…
Disease Models of ADHD
February 27, 2021
Attention Deficit Hyperactivity Disorder (ADHD) is a disorder that is characterized by inattention, hyperactivity, and impulsivity.[1] Symptoms include the…
Rodent Models of Hydrocephalus
February 15, 2021
Introduction Hydrocephalus is a disorder that is defined by an accumulation of cerebrospinal fluid (CSF) in the ventricles of the brain. It is a rather common…
Aging as a Disease Model and Therapeutic Target for Neurodegenerative Diseases
March 31, 2020
Aging is the progressive degeneration of physiological structure and function. Although people are living longer on average (thanks to improved medical…
Animal models of schizophrenia
January 14, 2020
Introduction to Schizophrenia Schizophrenia is a psychiatric disorder that is not only debilitating to the patient but also a heavy disease burden for the…
Rodent Models of Addiction
May 27, 2019
Introduction What is Drug Addiction? Despite the various mechanisms of action of the many abusable drugs, drug addiction looks largely the same from a…
Animal Models of Narcolepsy
May 23, 2019
Narcolepsy is a debilitating neurological disease affecting around 0.05% of the human population, men and women alike.[1][2] The disease is defined as the…
Rodent Models of Ischemic Stroke
May 18, 2019
Table of Contents Introduction to Ischemic Stroke Characteristics and Types of Ischemic Stroke Thrombotic Stroke Definition What is a Thrombus? Thrombotic…
Mice models of bipolar disorder
March 29, 2019
Introduction to Bipolar Disorder Bipolar disorder, originally termed manic-depressive disorder, is a devastating neuropsychiatric disease, which is…
Murine Models of Neurodegenerative Diseases
February 13, 2019
Neurodegenerative diseases comprise a class of disorders characterized by a progressive loss of neurological function, either by cell death or dysfunction. The…
An Overview of Mouse Models of Prion Disease
February 13, 2019
The intricate world of pathogens and diseases is expanding at an alarming rate. All pathogens, no matter how bizarre, follow the same patterns of replication.…
Rodent Models of Parkinson’s Disease: A General Overview
November 22, 2018
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, affecting 1% of individuals over the age of 60.[1] Though the disease was…
An Overview of Animal Models of Hemorrhage
August 3, 2018
Hemorrhage, the rupturing of a blood vessel within the brain, is the second most common type of stroke, seriously affecting millions of people annually. Yet,…
Opioid Induced Hyperalgesia
February 13, 2018
History of Opioid-Induced Hyperalgesia Chronic pain is a significant problem in both the United States and Europe. Research suggests it affects 30 – 40% of the…
A Guide To Animal Seizure Models
February 5, 2018
Translation, regardless of the medium it’s put to use, always consists of challenges and difficulties. Aiming for a perfect copy paste scenario is highly…
Animal Models of Pain
October 17, 2017
Pain Pain is a physiological and emotional response to a noxious stimulus. Pain receptors (nociceptors) throughout the body convey sensation from mechanical…
Obsessive Compulsive Disorder Mouse Models
October 10, 2017
Disabilities occupy a wide spectrum of types and form. Not being able to see, hear, walk, and talk are all heavy burdens to the affected and his or her…
Modeling Myelin: Multiple Sclerosis Mouse Model
August 28, 2017
Intrinsic neuronal fibers run up and down, side to side in the human body; biochemical highways which carry information that basically give meaning to the word…
Traumatic Brain Injury in Sports: Modeling Safer Methods
July 27, 2017
Content Introduction Symptoms Witnessed and Expected Animal Models: What We Have, What We Need Momentum Exchange Method Weight Drop Methods Hit and Run Method…
Animal Models of Depression
May 22, 2017
The development of preclinical animal models is an important step toward discovering new treatments for diseases. However, establishing animal models of…
The Basics of Depression Testing in Rodents
April 3, 2017
Major Depressive Disorder is one of the most common mental health diagnoses worldwide. Despite its astounding frequency, research has yet to uncover…
