Disease Models
Animal Models and Apparatus of Sleep Disorders
June 16, 2023
Sleep problems affect a significant portion of the population, with over half of people in the United States reporting difficulties with sleep or excessive…
Maximum Volume of Oxygen (VO2) Testing in Rodents
February 8, 2023
Maximum volume of oxygen (VO2max) is a measure of the maximum amount of oxygen that an individual can consume during exercise. VO2max is expressed in…

Rodent Models of Social Anxiety Disorders
November 19, 2021
Fear is something we try to do without in life – which is also the very reason they exist, to provide salient physical and psychological cues and help us…

Animal Models of Migraine Headaches
August 16, 2021
Migraines are best known for their severe, pulsating headaches, along with more variable associated symptoms such as hypersensitivity to lights and sounds,…
Neurological disease models are essentially experimental systems that can reproduce key features of neurological disease as seen in humans. They enable progress in scientific research. But, how are neurological disease models created and used in neuroscience and behavioral research? In this resource section, we cover the methods, ways, and behaviors associated with neurological disease models, as well as the assessments used for those particular disease models. Featured neurological disease topics range from seizures to PTSD to depression.
For related content, refer to our detailed articles on:
- Non-Neurological Disease Models: Non-neurological diseases can also affect behaviors. Here, we highlight the many non-neurological disease models used in neuroscience research.
- Animal Models: See how different types of animals, like sheep and pigs, are used in animal research and what they can teach us about behavioral neuroscience.
- Nutrition and Drugs: Browse through our growing catalog of nutrition and drugs where we explore the relationship between them and behavior. In many cases, disease models are also mentioned.
- Complex Behaviors: Learn how more complex behaviors, one which involve high levels of cognition, are modeled in animals. Topics covered include: meditation, vacation, modeling adolescence in mice, modeling sleep deprivation, and more.

Animal Models of Pain
October 17, 2017
Pain Pain is a physiological and emotional response to a noxious stimulus. Pain receptors (nociceptors) throughout the body convey sensation from mechanical…

Obsessive Compulsive Disorder Mouse Models
October 10, 2017
Disabilities occupy a wide spectrum of types and form. Not being able to see, hear, walk, and talk are all heavy burdens to the affected and his or her…

Modeling Myelin: Multiple Sclerosis Mouse Model
August 28, 2017
Intrinsic neuronal fibers run up and down, side to side in the human body; biochemical highways which carry information that basically give meaning to the word…

Traumatic Brain Injury in Sports: Modeling Safer Methods
July 27, 2017
Content Introduction Symptoms Witnessed and Expected Animal Models: What We Have, What We Need Momentum Exchange Method Weight Drop Methods Hit and Run Method…

Animal Models of Depression
May 22, 2017
The development of preclinical animal models is an important step toward discovering new treatments for diseases. However, establishing animal models of…

The Basics of Depression Testing in Rodents
April 3, 2017
Major Depressive Disorder is one of the most common mental health diagnoses worldwide. Despite its astounding frequency, research has yet to uncover…

Modeling Postpartum Mood Disorder
February 16, 2017
If you were to play a fill-in-the-blank game with a friend, the term “postpartum” would likely be followed quickly by “depression” or “blues”. While awareness…

Animal Models of Traumatic Brain Injury
January 16, 2017
Traumatic brain injury (TBI) is a major cause of disability affecting millions in the US yearly, with survivors often suffering from changed personalities,…

Studying Autism Behaviors in Animal Models
January 6, 2016
In this article we will discuss the various autism spectrum disorder (ASD) models used in behavioral neuroscience. We will also take a special look at the…

Alzheimer's Mouse Model
December 16, 2015
Several genes involved are implicated in Alzheimer’s Disease but the mechanism for the disease remains unclear, and is even variable between patients. As such,…

Ob/ob Mice
December 9, 2015
In the 1950s, Ingalls and colleagues discovered “some very plump young mice” in one of their mouse colonies. Obesity in mice is typically very rare, so the…

Water Associated Zero Maze for PTSD Modeling
November 19, 2015
The human response to trauma – even the same kind of trauma – is variable. Even a diagnosis of Post-traumatic Stress Disorder, or PTSD, does not mean that each…