Description
Development of a water-escape motivated version of the Stone T-maze for mice addresses the challenges in assessing learning and memory in mice using tasks originally designed for rats. Traditional reward-based tasks often yield inconsistent results with mice due to differing motivational factors. To overcome this, Pistell, P. J., & Ingram, D. K. developed a mouse-adapted Stone T-maze that leverages mice’s inherent motivation to escape to a safe environment.
In this modified maze, mice are required to wade through water to reach a dark, dry goal box, simulating an aversive scenario that encourages escape behavior. Successful navigation demands learning a specific sequence of 13 left and right turns to reach the goal. Through various experimental protocols, the study demonstrated that mice consistently performed this task, indicating its reliability in evaluating learning and memory. The authors propose that this water-escape motivated Stone T-maze serves as a valuable tool for cognitive assessment in mice, minimizing performance confounds associated with other tasks