Lesions of the nucleus accumbens in rats reduce opiate reward but do not alter context-specific opiate tolerance (Kelsey 1989)



  • The 20 x 49 x 31 cm shuttle box was made of galvanized steel except for the clear Plexiglas top.
  • The box was divided into two 20 x 24.3 cm interconnecting chambers by a partition that had a 7 x 8 cm opening in the center flush with the grid floor.
  • One chamber was painted black.
  • The other chamber was left the natural silver-gray tone of the metal. The grid floor was made of 0.6-cm-diameter stainless steel rods separated by 2.0 cm to center and running across the width of the two chambers.

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