Prefrontal cortex lesions differentially disrupt cocaine-reinforced conditioned place preference but not conditioned taste aversion (Isaac 1989)



  • The apparatus consisted of a rectangular box which had three chambers.
  • The two end chambers each measured 22 x 26 x 30 cm.
  • The smaller middle chamber measured 22 x 14 x 30 cm.
  • One of the end chambers was painted white, had a hardware cloth floor.
  • The other end chamber was painted black, had a grid floor constructed of parallel brass bars.
  • The smaller middle chamber was painted gray and had a solid wooden floor. Guillotine doors separated the middle chamber from the end chambers.

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